Hey friend,

​U.S. life expectancy is falling behind that of similar-sized and high-income countries, at 78.4 years compared to 82.5 years elsewhere.

Might tripping on psilocybin mushrooms be the answer to life extension?

And not only living longer… but aging better?

A new Nature study found that psilocin—the compound psilocybin converts into—extended the lifespan of human skin and lung cells by over 50%.

In aged mice of 19 months (equivalent to 60–65 human years), a low dose followed by monthly high doses of psilocybin for 10 months—a total of 10 doses—boosted survival by 30%, improved fur quality, reduced white hairs, and even promoted hair regrowth.

Researchers now suggest psilocybin could be a revolutionary anti-aging therapy.

While that’s remarkable, information is useless without application!

Today, I want to help you take these insights and turn them into practice.

Psilocybin mushroom longevity protocol

Here’s how I’d turn these new psilocybin longevity findings into a practical anti-aging protocol:

Macrodose sessions

To start, I’d take quarterly psilocybin sessions, ranging from a standard to heroic dose—about 3.4 to 5.1 grams of average-potency Psilocybe cubensis for my bodyweight (170 lbs).

If you want to find your own standard to heroic dose range, based on your bodyweight (kg/lbs) and psilocybin mushroom species…

• ​Here’s my go-to dosing calculator​

The mice in the study were given monthly high doses, but that cadence isn’t realistic for most people, myself included.

To bridge that gap, I’d supplement with microdosing between sessions.

Microdose protocol

Microdosing means taking a tiny, sub-perceptual dose of a psychedelic—like psilocybin mushrooms—enough to boost brain function without hallucinations.

Dosage

A typical microdose is about 10–20% of a standard psychoactive dose, usually 100–350 mg of dried mushrooms (depending on species/strain).

For me, with a standard dose of 3.4 g, my microdose range falls around 70–300 mg. *My personal sweet spot is ~150 mg.

*Your sensitivity and tolerance may differ from mine, so always tailor your dose to your own body.

Schedule

You don’t want to microdose daily. Instead, use a rhythm:

• Fadiman Protocol — Dose on day 1, take 2 days off, repeat.
• Stamets Protocol — Dose 4 days in a row (Mon–Thurs), take 3 days off, repeat.

Duration

Microdosing is best done in cycles, rather than indefinitely. I like a 2:1 ON-to-OFF ratio.

• For example: 8 weeks on → 4 weeks off.

To fuse this into the Psilocybin Longevity Protocol, I align my macrodose sessions during the “off” phase, when tolerance has reset to baseline.

Microdose stack

I wouldn’t stop at microdosing alone, I’d stack it.

Meaning, I’d layer in herbs, supplements, and nutraceuticals that amplify its effects, creating a high-impact anti-aging formula.

Here’s what that stack would look like:

• NAD+ precursor (NR or NMN): Fuels cellular energy and longevity.
• Resveratrol: The red grape-skin compound linked to anti-aging.
• Senolytic: Clears out senescent (“zombie cells”) cells that accelerate aging.
• Curcumin: The polyphenol in turmeric—reduces inflammation, fights oxidation, and boosts BDNF.
• PQQ + CoQ10: Supports mitochondrial function and mitochondriogenesis (new mitochondria).
• Adaptogens (Eleuthero, Rhodiola, Ginseng, Reishi): Combat stress, lower inflammation, and support resilience.

Integration

To bring it full circle, I take a holistic approach to psychedelics. Dosing alone isn’t enough to support true well-being.

Integration means taking the insights from macrodose sessions, applying them in daily life, and leveraging the neuroplastic boost from both macrodosing and microdosing to nourish mind, body, brain, and soul.

A few anti-aging integration practices you can weave into your longevity protocol:

• Cyclical ketogenic diet
• Intermittent fasting (16/8, 18/6, 20/4, or 5:2)
• Meditation or neurofeedback
• Breathwork or somatic practices
• Nature time (Shinrin-Yoku)
• Community bonding
• Sleeping like a baby

The bottom line

American lifespan is declining… and so is health-span, which I’d argue matters even more.

Tomorrow isn’t promised, but today can be lived fully, vibrantly, and with vitality.

For me, it’s not about simply stretching life for the sake of more years. It’s about adding life to your years, not just years to your life.

Because who wants to merely endure illness when you could thrive instead?

A longer life should be the bonus, not the goal.

That’s where I diverge from the anti-aging bros, like Bryan Johnson. His mission—literally summed up by the slogan “Don’t Die”—feels more rooted in fear of death than in fully living.

I see psilocybin research differently.

Its longevity-promoting potential isn’t just about adding years, but about staying resilient and youthful as we age.

To me, that’s what it really means to “suck the marrow out of life.”

What do you think?

Onjae

P.S. I just launched my new course, Mindful Microdosing—built to help you microdose the right way. Inside, you’ll learn how to craft a high-impact protocol to support mental health, longevity, and peak cognitive performance!